How to Store Your GLP-1 Medication: Temperature, Light, and Shelf Life

The Golden Rule: Keep It Cold

Your compounded GLP-1 medication must be stored in the refrigerator at 36°F to 46°F (2°C to 8°C). This temperature range maintains the medication's potency and prevents degradation of the active peptide. Do not freeze your medication — freezing permanently damages the molecular structure and renders it ineffective.

Refrigerator Storage Best Practices

Store your medication in the main body of the refrigerator — not in the door. Refrigerator doors experience more temperature fluctuation every time the door is opened. Keep the vial upright and away from the cooling element at the back of the refrigerator to prevent accidental freezing.

Keep the vial in its original packaging or a small opaque container to protect it from light. Prolonged exposure to light can degrade the peptide over time.

Shelf Life

Compounded semaglutide and tirzepatide vials are typically stable for 28–56 days when refrigerated, depending on the formulation and pharmacy. Check the expiration date printed on your vial label. Do not use medication past its expiration date even if it looks and smells normal — peptide degradation is not always visible.

Traveling With Your Medication

When traveling, keep your medication in an insulated travel cooler with an ice pack. Do not place the vial directly against the ice pack — wrap it in a cloth or place a barrier between the vial and the ice to prevent freezing. Most compounded GLP-1 medications can be kept at room temperature (below 77°F / 25°C) for up to 14 days without significant loss of potency.

When flying, always carry your medication in your carry-on bag — never in checked luggage. Cargo holds can experience extreme temperatures. TSA allows medically necessary liquids in quantities greater than 3.4 oz when properly labeled. Carry a copy of your prescription and a letter from your physician if traveling internationally.

What to Do If Your Medication Was Left Out

If your medication was accidentally left at room temperature (below 77°F / 25°C) for less than 14 days, it is generally still safe to use. Return it to the refrigerator as soon as possible. If it was left out for more than 14 days, or exposed to temperatures above 86°F (30°C), discard it and contact your RxVigor care team for a replacement.

If your medication was frozen, do not attempt to thaw and use it. Freezing causes irreversible protein denaturation. Discard the vial and contact [email protected] for assistance.

Signs That Your Medication May Be Compromised

Inspect your medication before each injection. Discard and contact your care team if you notice:

• Visible particles or cloudiness (the solution should be clear and colorless)
• Discoloration (any yellow, brown, or pink tint)
• An unusual smell when opening the vial
• Crystals or precipitate at the bottom of the vial